Source: Strauss, S. E. Evidence-Based Medicine: How to Practice and Teach EBM. New York: Churchill Livingstone, 2005.
PICO - a method of putting together a search strategy that allows you to take a more evidence based approach to literature searching when searching bibliographic databases.
P is for the Patient or the Problem (e.g. a disease or condition) or Population of interest - who or what?
I is for Intervention (e.g. therapy, procedure, drug, exposure, test, strategy) or indication - how?
C is for Comparison (e.g. compared to an alternative intervention or an experimental control - what is the main alternative?
O is for Outcome (i.e.the consequence, effect or improvement of interest) - what are you trying to accomplish, measure, improve, effect?
|P||Population / Patient / Problem|
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