Bile acid sequestrants are cholesterol-lowering medication that reduces blood glucose levels for patients with diabetes. The action of the drug works by binding with bile acids. Bile acids are acids formed in the liver that help to break down fats in the body. The bile acid in the digestive system binds to the LDL cholesterol that is then excreted through the feces. As a result, the amount of cholesterol in the bloodstream is lowered. Speak to your healthcare provider if you experience cramps or intensified hemorrhoids from taking this medication.